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pentobarbital will lessen the extent or outcome of colchicine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.Barbiturates can induce hepatic microsomal enzymes resulting in improved metabolism and lowered anticoagulant reaction of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); suffe